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Northwestern University Feinberg School of Medicine
Institute for Global Health

Center for Global Cardiovascular Health

We seek to improve global cardiovascular health and healthcare across the spectrum of disease prevention.

Cardiovascular diseases are the leading cause of death and disability globally. Out of 54 million deaths each year, one-third (18 million) are caused by some form of cardiovascular disease. As of 2015, there are an estimated 422 million individuals living with prevalent cardiovascular diseases, with 7 million fatal heart attacks and 9 million fatal strokes each year. Most (80 percent) events occur in low- or middle-income country settings where they are also more likely to occur prematurely (younger than 70 years).

The Center for Global Cardiovascular Health aims to bridge the gap between the world we live in and the world we aim to get to. Imagine a world where every person who has an acute cardiovascular event receives timely, high-quality care no matter where they live, where individuals with cardiovascular disease are supported to optimize their health behaviors and adherence to simpler, lower-cost medications that are tailored to their needs, where the food supply supports cardiovascular health and almost no one uses tobacco. This picture is very different than the world in which we live where individuals who have acute cardiovascular diseases receive highly heterogeneous care, where most individuals with cardiovascular disease take zero medications to prevent a recurrent event, where the food supply is rife with junk food and where 20 percent of the world uses tobacco.

"What will it take to get us from where we are now to a world where ideal cardiovascular health and health care are normative? This fundamental question drives the center’s vision and collective actions."

Mark Huffman, MD, MPH, Director, Center for Cardiovascular Health

Director

Featured Projects

QUARTET USA

QUARTET USA

Northwestern Faculty and Staff: PI Mark Huffman, MD, MPH, and Jody D Ciolino, PhD; Abigail Baldridge, MS; Namratha R. Kandula, MD, MPH; Donald M. Lloyd-Jones, MD, ScM; Stephen D. Persell, MD, MPH; James Paparello, MD; Swapna Dave, MPH, PMP, MBBS; Sadiya Khan, MD, MS; Mianzhao Guo

QUARTET USA is a phase II randomized trial testing the effect of a four-drug, quarter-dose blood pressure lowering combination among individuals with hypertension in federally qualified health centers in Chicago as part of the global QUARTET program (trial ongoing in Australia and in development in The Netherlands and Japan). This trial represents a reverse innovation of using fixed-dose combination, or polypill, therapy for cardiovascular disease prevention within a U.S. population that bears one of the highest burdens of hypertension-related illness in the world.

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Pragmatic Clinical Trials for Chronic Disease Prevention & Treatment

Pragmatic Clinical Trials for Chronic Disease Prevention & Treatment

Northwestern faculty: Juned Siddique, DrPH

The goal of this project is to develop collaborations with scientists at the CRONICAS Center of Excellence in Chronic Diseases at the Universidad Peruana Cayetano Heredia on the design, implementation and analysis of large-scale pragmatic clinical trials for the prevention and treatment of chronic diseases in vulnerable populations. Siddique will accomplish this through statistical consulting, teaching, analysis of existing CRONICAS data and statistical methods development. The long-term goal of this exchange is to start a relationship between Northwestern University and UPCH and encourage the exchange of fellows, students and faculty between the two institutions.

Funding: Fulbright U.S. Scholar Award, 2019-2020

Partners: CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia

See Siddique Faculty Profile
International Ten-Day Teaching Teaching Seminars in Cardiovascular Disease Epidemiology and Prevention: 2020

International Ten-Day Teaching Teaching Seminars in Cardiovascular Disease Epidemiology and Prevention: 2020

Northwestern Faculty and Staff: Darwin Labarthe, MD, PhD, MPH; Jeremiah Stamler, MD

Cardiovascular diseases and stroke are the leading cause of death and disability in most countries in the world, as they have been over many decades.  To address this global health challenge, the seminars were founded in 1968 by Professors Jeremiah and Rose Stamler and Richard Remington from the USA, and Professor Geoffrey Rose from the UK.  Initial support was provided by the International Society and Federation of Cardiology (since 1998, World Heart Federation) Council on Epidemiology and Prevention and the Cardiovascular Disease Unit of the World Health Organization in Geneva. From 2008, the sponsor has been the International Society of Cardiovascular Disease Epidemiology and Prevention (ISCEP).  The 50th International Seminar was convened in Goa, India, in 2018, and plans are being made for the 51st and beyond.

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Heart Attack Care in India

Heart Attack Care in India

"Acute Coronary Syndrome Quality Improvement in Kerala"

Northwestern Faculty and Staff: PI Mark Huffman, MD, MPH; Abigail Baldridge, MS; Donald M. Lloyd-Jones, MD, ScM; Lihui Zhao, PhD

This stepped wedge, cluster randomized trial was the largest cardiovascular randomized trial in India and demonstrated improvements in process measures among 21,374 patients with heart attacks who were recruited from 63 hospitals in Kerala, India, from 2014 to 2016. The trial also reported health-related quality of life and individual- and household-level costs among heart attack survivors and served as a training hub/model for seven Fogarty-funded Northwestern global health fellows.

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World Heart Federation

World Heart Federation

"World Heart Federation Salim Yusuf Emerging Leaders Programme"

Northwestern Faculty and Staff: Mark Huffman, MD, MPH; Darwin Labarthe, MD, PhD, MPH; Abigail Baldridge, MS; Namratha R. Kandula, MD, MPH

This first-of-its-kind training program in implementation science, health systems and health policy was co-created by Huffman, Labarthe and Salim Yusuf in 2014. The program has trained 125 Emerging Leaders from 49 countries over its first five years and features a rotating theme each year.

 

Learn more about the program
Improving Access to Essential Cardiovascular Medicines

Improving Access to Essential Cardiovascular Medicines

Northwestern Faculty: Mark Huffman, MD, MPH

The Center for Global Cardiovascular Health aims to improve access to essential cardiovascular medicines by working through the World Health Organization and national model lists of essential medicines and has contributed to the addition of clopidogrel and direct oral anticoagulants to the World Health Organization list, among other changes. An independent study course is offered through the Program in Public Health for students to develop and submit applications to the World Health Organization’s list on a biennial basis.

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About Our Center

Fogarty Fellows

Meet the NIH/Fogarty global health fellows and early stage investigators supported by our center.
Meet the Fellows

Advisory Boards

Meet the internal and external experts who provide strategic guidance to the center.
Advisory Boards

Center Goals

Learn about the goals that drive our center's work.
Center Goals

Publications

Learn more about the work we do via our listing of recent publications.
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Be a part of our future commitment to improving the lives of patients around the world.

Giving
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